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In this regard, PK activity enhancement can be thought to mitigate the instability of the HS RBC membrane by replenishing ATP stores that are then used in the ion-pump activities (24), acceleration of glutathione (GSH) synthesis, and a feed-forward loop for glycolysis itself (7, 25, 26)

It reflects the shift between carbohydrate and fat oxidation, directly affecting exercise endurance

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Information on the supplement This article is part of the supplement entitled Clinical Practice Guideline for detection and management of diabetic kidney disease: a consensus report by the Spanish Society of Nephrology, sponsored by the Spanish Society of Nephrology, with funding from Mundipharma