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Side Effects Led More People to Stop Taking Orforglipron Than Its Rival Pill With both GLP-1 pills, the most common side effects were gastrointestinal issues such as nausea, diarrhea, vomiting, and indigestion, per Lilly

Emotional eating is often driven by food noise, causing people to eat beyond their actual physical hunger

"There has never been a medication or class of medications that has worked for obesity in this way," says Christopher McGowan, MD , an obesity medicine specialist in Cary, North Carolina

The cagrilintide mechanism of action centers on mimicking the natural hormone amylin, which is normally co-secreted with insulin from pancreatic beta cells