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Several NADPH oxidases may play a role in blood pressure control (21), and ROS from NADPH oxidases can also trigger adaptive signaling that improves glutathione replenishment via redox-dependent increases in glutathione reductase activity

Desbois-Mouthon C, Wendum D, Cadoret A, Rey C, Leneuve P, Blaise A, Housset C, Tronche F, Le Bouc Y, Holzenberger M: Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout

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The non-enzymatic mitochondrial protein hyperacetylation induced by the increased availability of mitochondrial acetyl-CoA avoids the risk associated with mitochondria overfeeding, restraining the activity of the respiratory complex I and modulating CACT activity