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10.1093/jnci/djr475 10.1093/jnci/djr475 [DOI] [PMC free article] [PubMed] [Google Scholar] Ottaviano FG, Handy DE, Loscalzo J (2008) Redox regulation in the extracellular environment

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Thioredoxin reductases (TXNRDs) employ NADPH as an electron donor to revert oxidized TXN to a reduced dithiol, the oxidation status of which is critically implicated in regulating various cell behaviors including proliferation and apoptosis 51