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Circulating peroxidized lipids Lipid peroxidation products in the blood, such as malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and isoprostanes, directly reflect the oxidative membrane damage central to ferroptosis [388]

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Combined treatment with ovastatin and lovastatin (a cholesterol-lowering agent) inhibited epidermal growth factor-induced migration of anaplastic TC cells ( in vitro and in vivo mouse model of anaplastic TC showed that troglitazone + Lovastatin display anti-cancer effects such as reduction of cell proliferation and tumor regression (Zhong et al., 2018)