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The main culprits include: Ultraviolet and visible light exposure the strongest daily stimulator Hormonal fluctuations (pregnancy, contraceptives, thyroid changes) Inflammation from acne, eczema or injury (post-inflammatory hyperpigmentation) Ageing and genetics Certain medications or skin trauma Globally, pigmentary disorders affect a significant portion of the population, with surveys showing around half of adults reporting at least one pigmentation concern

A systematic review of the prevalence of depression, anxiety, and apathy in frontotemporal dementia, atypical and young-onset Alzheimers disease, and inherited dementia

PMID 28032133

J Biol Chem, 1998