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This was done for practical reasons at an early stage in development when there was uncertainty about potential adverse consequences of ActA blockade on reproductive potential (see Supplementary Results for complete details of the preclinical studies)
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7,8-Dimethoxycoumarin A natural coumarin compound present in various plants, called 7,8-dimethoxycoumarin, possesses anti-secretory, anti-inflammatory [206], antioxidant properties, and the ability to treat acute renal failure [157]
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