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Outputs from the model include total (discounted) direct healthcare costs associated with treatments for diabetes and treating complications, as well as indirect costs (i.e., societal perspective costs associated with labour market productivity losses), cumulative histories of complications, total (discounted) life-years and quality-adjusted life years, and incremental cost-effectiveness ratios

36 showed that the neurotoxic activation of microglia with LPS can be reduced in the presence of elevated UA, an effect shown to be mediated by cellular UA uptake