To evaluate the effects of compound on GPX4 activity, compound was first pre-incubated with purified GPX4 in the assay buffer [Tris-HCl (100 mM, pH 7.4), EDTA (5 mM), Triton X-100 (0.1% v/v), NADPH (0.2 mM), glutathione (3 mM), and glutathione reductase (1 unit)] for 5 min at 37C
GLP-1 microdosing refers to using smaller-than-recommended doses of GLP-1 receptor agonists, the type of medicine commonly prescribed under brand names like Ozempic and Wegovy
Astaxanthin and vitamin C are both antioxidants, but for sensitive, reactive, or barrier stressed skin a stable astaxanthin serum like PowerV is usually the gentler, lower risk choice
However, there are still many opportunities for translational insight as the field grows