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The analyses presented in this paper are based on trial populations largely without baseline cardiovascular risks, and we have not investigated the potential impacts of including cardiovascular effects captured in CVOTs

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doi: 10.3389/fphar.2021.718147 Received 09 June 2021 Accepted 17 November 2021 Published 13 December 2021 Volume 12 - 2021 Edited by Fan Jiang, Shandong University, China Reviewed by Dechang Chen, Shanghai Jiao Tong University, China Ying Li, Xian Jiaotong University, China Updates Copyright 2021 Tepes, Gojkovic, Krezic, Zizek, Vranes, Madzar, Santak, Batelja, Milavic, Sikiric, Kocman, Simonji, Samara, Knezevic, Barisic, Lovric, Strbe, Kokot, Sjekavica, Kolak, Skrtic, Seiwerth, Boban Blagaic and Sikiric

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