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Murru A, Sommerhoff C

Cystic fibrosis, usually due to severe mutation in bothalleles of the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene, causes an accelerated non-calcific form of chronic pancreatitis that begins in utero : oxidative stress and inflammation are now regarded as integral features of the disease, driven by unfolded CFTR via the ER stress-UPR system (121, 177)

Aging Cell 18 , e12895, (2019)

With respect to plasma acyl-carnitines, the individuals with schizophrenia at baseline showed significantly higher levels of C4-OH (C3-DC) and C16:1, but lower concentrations of C3, C8, C10, C10:1, C10:2, C12, C14:1-OH, C14:2, and C14:2-OH when compared with healthy controls after controlling for age, sex, body mass index (BMI), smoking, and drinking