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Key Points The insulin-like growth factor 1 ( IGF1 ) gene is a major target of growth hormone IGF1 binds the IGF1 receptor (IGF1R) with high affinity and the insulin receptor with low affinity

Per the systematic review of 118 trials, the effect is "moderate but meaningful", which means it's not a magic bullet, but it significantly improves outcomes, especially for the heavy-drinking pattern that causes most of the harm

Unlike some medications, most GLP-1 injections can be taken with or without food, so you have some flexibility there