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The initial muscle loss seen with GLP-1 RA treatment as well as the ongoing replacement of muscle with fat with treatment cycles involving treatment interruptions can result in unfavorable changes in body composition in patients with obesity that can have profoundly negative repercussions, and can exacerbate obesity-related metabolic and health concerns 14,15,16

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In the meantime, Eli Lilly should remain the leader in weight loss thanks to Zepbound, and other highly promising pipeline candidates, such as retatrutide, whose recent phase 3 results have been compared to what we typically see in bariatric surgeries

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