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The physiological significance of that endogenous GLP-1 nudge is almost certainly negligible when you have pharmacological GLP-1 already circulating

The core of the dispute revolves around the "compounding loophole." While compounding is permitted for individual patient needs (e.g., allergies, specific dosages) or when approved medicines are in short supply, Novo Nordisk argues that its GLP-1 drugs are no longer on the FDA's shortage list

Several critical research gaps remain