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Moreover, the SYNERGY-NASH trial showed that tirzepatide was associated with a dose-dependent greater likelihood of biopsy-proven MASH resolution vs

Effects on Fibrosis (Tissue Stiffness) Fibrosis is a hallmark of lipedema and contributes to: Pain Tissue hardness Reduced response to treatment Tirzepatide has shown antifibrotic effects in other conditions (like fatty liver disease), suggesting it may help improve tissue quality over time

Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis

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