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In A Treatise on the Scurvy (1753) [2] [61] [59] Lind explained the details of his clinical trial and concluded "the results of all my experiments was, that oranges and lemons were the most effectual remedies for this distemper at sea." [8] [59] However, the experiment and its results occupied only a few paragraphs in a work that was long and complex and had little impact

161 The primary endpoint was the reduction in weekly heartburn episodes, while secondary endpoints included GERD-related symptoms, patient satisfaction, and safety

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