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Because it inhibits the proliferation of Treg cells, leptin, a pro-inflammatory adipocytokine, is unusually increased in SLE patients and speeds up the course of lupus nephritis (232, 233)
Drug shortages: The off-label demand for these medications can create shortages, making it harder for diabetic patients to access life-saving treatment
Furthermore, with disconcertingly low persistence rates undermining the opportunity for longer term AOM treatment, behavioural support programmes utilising digital health tools will open up a new front-line for competition in 2025, with the need to demonstrate real-world impact on patient outcomes
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