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Recently, glutamine-related metabolic pathways, such as the glutamine-glutamate-GSH pathway, glutamine-glutamate--KG-2-HG pathway, and glutamine-mTOR signaling, which participate in regulating Th17/Treg cell differentiation, have been identified ( 4 Glutaminolysis in autoimmune diseases Under normal conditions, the activity of T cells is controlled by immune tolerance mechanisms that distinguish between autologous and nonautologous components and specifically recognize and react against pathogens ( 4.1 Systemic lupus erythematosus Systemic lupus erythematosus (SLE) is defined as a chronic, recurrent autoimmune disease with recurrent episodes of tissue inflammation and severe multiorgan damage mediated by the bodys autoimmunity ( via the reduction of HIF1

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In conclusion, metformin has demonstrated many therapeutic advantages in the treatment of patients with PCOS across multiple life stages, including puberty, pregnancy, and long-term health management