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Sirtuin activity declines proportionally with NAD+ levels, reducing stress resistance and promoting cellular senescence

Additionally, the weight loss was superior compared with what adults achieved with semaglutide 2.4 mg alone (Wegovy, Novo Nordisk) or cagrilintide 2.4 mg alone (Novo Nordisk)

Chen TS, Richie JP Jr, Lang CA

When their seminal research was published in *Cell* in March 2017, it introduced the first precision senolytic peptide capable of selectively eliminating senescent cells while sparing healthy tissue, opening unprecedented opportunities for studying aging mechanisms and developing research tools for age-related cellular dysfunction