According to the American Diabetes Association's Standards of Care, GLP-1 RAs with proven cardiovascular benefit, such as semaglutide, may be considered as first-line therapy in patients with type 2 diabetes who have established atherosclerotic cardiovascular disease or high cardiovascular risk, independent of metformin use
Availability depends on the patients physical location, clinician licensure, medical needs and applicable prescribing rules
Additionally, some weight loss pills can potentially interact with other medications, leading to adverse effects
In SUSTAIN 6, the largest trial investigating semaglutide, with the longest duration reported to date in subjects with high cardiovascular risk, mean pulse rate increases of 2.1 and 2.4 bpm were reported with semaglutide 0.5 and 1.0 mg, respectively, versus no change with placebo