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The inhibition of ERK5 and ERK1/2 could synergistically cause MYC loss and inhibit mutant KRAS during pancreatic cancer cell growth, as ERK1/2 inhibition could induce activation of the EGFRMEK5ERK5 cascade [56, 57]

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doi: 10.1002/wsbm.1644, 143 ZhangW.LiuY.LiaoY.ZhuC.ZouZ