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Patients should contact their healthcare provider if they experience any of the following: Severe or worsening fatigue that interferes with daily activities, work, or self-care, or fatigue that progressively worsens despite implementing management strategies

Before treatment, individuals may have noticed visible signs of aging, particularly around the eyes and mouth

Additionally, there have been rare reports of non-arteritic anterior ischaemic optic neuropathy (NAION) in observational studies of semaglutide, though a causal relationship has not been established and regulatory authorities continue to monitor this signal

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