112 More recently, it was suggested that methotrexate causes ferroptosis through activation of autophagy, leading to increased degradation of ferritin and liberation of ferrous iron (ferritinophagy), which promotes LPO and liver injury
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doi: 10.3389/fphar.2025.1719384 Received 06 October 2025 Revised 01 November 2025 Accepted 03 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Gvozden Rosic, University of Kragujevac, Serbia Reviewed by Kandasamy Neelamegam, Tulane University, United States Ciniraj Raveendran, Government Medical College, India Updates Copyright 2025 Yan, Song, Zhang, Hu, Wang, Guo, Wang, Ma and Liu