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What the Clinical Evidence Shows While large-scale randomized controlled trials specifically measuring testosterone as a primary endpoint in tirzepatide users are still emerging, the available evidence is encouraging: The SURMOUNT trials demonstrated average weight losses of 15-22.5% of body weight, a degree of fat reduction strongly associated with testosterone recovery in men with obesity-related hypogonadism (Jastreboff et al., 2022, NEJM )

It is administered weekly on the same day, at any time, with or without food, via subcutaneous injection in the abdomen, thigh, or upper arm

Uridine monophosphate, folic acid and vitamin B 12 in patients with symptomatic peripheral entrapment neuropathies