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Improves survival under oxidative stress by increasing nitric oxide (NO) expression, thereby protecting the endothelial lining of the blood vessels from oxidative damage

It acts through a different pathway the ghrelin receptor amplifying the GH pulse and making the pituitary more responsive to GHRH signals

However, one factor responsible for the limited effectiveness of B cell depletors in progressive MS may be resistance of leptomeningeal inflammation to even intrathecally administered agents for reasons that are not understood (Bhargava et al., 2019)