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EGCG is effective in inhibiting GDH, but has not been used clinically due to poor intestinal absorption, instability in solution and low bioavailability [4]

This gap emphasizes the critical need for integrated, multidisciplinary, and sustainable care strategies to support long-term behavioral change ( The presence of complex comorbidities in a subset of participantssuch as syndromic or hypothalamic obesity, neurodevelopmental disorders, and chronic systemic diseasesmay influence therapeutic responsiveness, potentially attenuating the magnitude of treatment effects

doi:10.1007/s00125-016-3996-2 85

Estimation of liver function parameters Aspartate aminotransferase (AST), alanine aminotransferase (ALT) were assayed in serum samples obtained from all groups of mice by a colorimetric method of Reitman and Frankel (Reitman and Frankel, 1957), while albumin was assessed according to the method of Pinnell and Northam (Pinnell and Northam, 1978) using commercially available kits (Diamond Diagnostic, Egypt) and the Erba CHEM-7 device (ERBA Diagnostics, India)