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However, there are a few rare cases where this treatment is not recommended

But medical literature evidence suggests these same pathways may interfere with key skin functions by: Slowing fibroblast activity, reducing the production of structural proteins like collagen and elastin Decreasing cell turnover, leading to dullness and slower skin renewal Compromising the skin barrier, increasing water loss and sensitivity to environmental damage The result

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"Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma."