does semaglutide cause irritability What Ozempic to your brain: Effect on appetite, mood & more can semaglutide cause mood swings

Side effects may often be eased by adjusting the dose-escalation schedule, which a licensed healthcare provider can help with

If you experience breakthrough bleeding or other signs of reduced contraceptive effect, consult your gynecologist or primary care provider to discuss alternative contraceptive methods or semaglutide dosing adjustments

However, published case reports and a 2024 retrospective cohort in Thyroid (N=112 patients on stable levothyroxine who started semaglutide) found that 28% required a TSH recheck within 6 months because of new hypothyroid symptoms or rising TSH, compared with 9% in a matched control group not starting GLP-1 therapy [7]

Nature Reviews Endocrinology , 17(12), 757769