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Complementing these findings, a one-year randomized controlled trial by Villareal and colleagues demonstrated that obese older adults who achieved a 10.1% weight loss through combined diet and exercise experienced significant decreases in hip BMDincluding the trochanter and femoral neckwhile spine and whole-body BMD were preserved

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Poor filtration, dehydration, low buffering capacity, impaired adenosine metabolism and reduced kidney reserve may all contribute to this bottleneck

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