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The guidelines came about following a period that saw an unprecedented increase in the available evidence regarding the CV safety of novel glucose-lowering agents with for the first time in the history of diabetes evidence for the improvement in CV outcomes

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At concentrations lower than those of DON, JHU395 has been found to decrease the growth and increase the apoptosis of high-MYC medulloblastoma cell lines, thereby prolonging the survival of treated animals (100)

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