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Images were recorded with a MegaView III CCD cooled digital camera (Soft Imaging Systems, Germany) at 10,000 80,000 magnification

With the fresh clinical data at their disposal, the drugs sponsor can start filing for marketing authorization

However in our opinion, the low probability of MS coincidence with another rare disease, together with the animal studies where MS is never a consideration, makes it more likely that these human examples align with an inside-out model (Figure 2), where a primary biochemical derangement of myelin, coupled with an immune predisposition, culminated in a MS-like phenotype

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