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J Periodontol 2009

Common plateau scenarios include: The circulation bottleneck: repair stalls because nutrient delivery is insufficient The remodeling bottleneck: pain improves but stability does not return The inflammation bottleneck: repair attempts are repeatedly interrupted by flare cycles The structure bottleneck: collagen forms but remains disorganized and weak GLOW is designed to support these simultaneously

Senescent cells survive by sequestering p53 through FOXO4 interaction

It is also useful when pain around a joint appears to be driven by surrounding tendons, ligaments, fascia, or connective tissue rather than severe damage inside the joint itself