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Patients lose fat differently, and some areas dont respond to GLP-1s

Retatrutide : Single-molecule triple agonist targeting GIP, GLP-1, and glucagon receptors simultaneously

In a trial by Iepsen et al., 37 women with an average age of 46 (Standard Deviation: 2 years, range 18-65 years) and BMI of 34 (SD: 0.5 kg/m 2 ) achieved a 12% weight loss after 8 weeks of low-calorie diet modifications