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To test whether cell Barr1 deficiency affected M 3 and GLP-1 receptormediated insulin release in vivo, we injected control and -barr1-KO mice with bethanechol (2 mg/kg i.p.), a muscarinic receptor agonist, or exendin-4 (12 nmol/kg i.p.), a GLP-1 receptor agonist

These include but are likely not limited to chronic hyperglycemia, hypertension, dyslipidemia, obesity, insulin resistance, sodium retention, neurohormonal activation and low-grade inflammation, all related to the metabolic syndrome [9, 10]

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A workplace simulation study also showed better sustained attention from 2 to 14 hours post-dose