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This reparative effect is mediated, at least in part, through the upregulation and reorganization of key regulatory proteins, most notably protein kinase C (PKC) and the tight junction scaffolding protein zonula occludens-2 (ZO-2), thereby facilitating the reassembly and functional recovery of the tight junction complex (161)

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At the same time, collagen stimulation and regenerative activity initiated by it may continue long after administration

Interestingly, people living near the Arctic circle present lower conception rates during winter darkness, when melatonin levels are high, than in summer