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Forty HIV-infected patients taking a stable HAART regimen for at least 3 months and who developed symptoms of DSP after beginning either stavudine and/or didanosine were randomized at each study site using a random block design to receive either the micronutrient supplement or an identically appearing placebo taken twice daily for 12 weeks

Studies show that it can help lower triacylglycerols (the most common type of fat in the human body) and LDL (bad) cholesterol levels, and conversely increase HDL (good) cholesterol levels, which in turn helps to maintain proper functioning and health of the cardiovascular system

This could make other pain treatments, like physical therapy or exercise, more effective

Some studies cited in a 2025 review noted that while proline can protect cells at low levels, when metabolized by the enzyme proline oxidase it produces reactive oxygen species (ROS)