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28 The challenge to develop an oral preparation for semaglutide ascribes by a hydrophilic, macromolecular peptide is naturally susceptible to low pH and gastric/intestinal enzymes, as well as poor gastrointestinal absorption

Most people who transition from semaglutide to tirzepatide have hit a wall of some kind, whether that wall involves stalled weight loss , persistent side effects, or simply wanting better results based on the clinical data now available

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