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However, mutations of LRRK2 or PINK1 can disturb the LRRK2PINK1 kinase balance, leading to increased TH and DA levels and dopaminergic neuron vulnerability

Glutathione (GSH) neutralizes these radicals, protecting brain cells

Pertinent to epilepsy, mice lacking mitochondrial SOD ( Sod2/ ) and heterozygous animals ( Sod2+/ ) show higher seizure susceptibility and concomitant degeneration, introducing the notion that O 2 are key players in the long-term brain changes after a seizure episode [22,23]