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Urine calcium concentrations dropped in people who entered the study with high urinary calcium, but not in those with normal urinary calcium (Yasui 2001)

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Experiment with both morning and nighttime supplementation for a few weeks to see which timing yields the best results for you

Other clinical bispecific mAbs, retaining the Fc for half-life extension, require additional mutations, including in the CH3 domain of the Fc to generate heterodimers (e.g., Fab-arm exchange/knobs-into-holes), as well as LALA or STR mutations to limit endogenous FcR interaction