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A healthy diet and lifestyle will reduce the likelihood of constipation and encourage a regular bowel habit

This improves the quality of life for patients

The metabolism and elimination of NAD+ (and its by-products) could be altered in advanced hepatic or renal dysfunction, and high-dose NAD+ might theoretically affect cardiovascular dynamics, so practitioners generally avoid or closely supervise NAD+ use in such settings

Additionally, a negative correlation between complex II activity and oxidative stress measures has been reported in BD patients during depressive episodes, suggesting that mitochondrial oxidative stress related mitochondrial dysfunction may contribute to bipolar depression [50]