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In AWARD-10 [31], a 24-week, randomized, double-blind, placebo-controlled trial evaluating once-weekly dulaglutide (administered at either 1.5 or 0.75 mg) as add-on therapy to SGLT2is in a total of 424 patients with inadequately controlled T2DM, only one episode of severe hypoglycemia was reported throughout the study, in a patient treated with dulaglutide 0.75 mg, confirming the very low incidence of serious hypoglycemia with GLP-1RAs in combination with SGLT2is [31]

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32 Fortunately, successful introduction of GLP-1 drugs into clinical practice has facilitated more detailed study of GLP-1 effects on bone health in the human setting ( Figure 3 )

You might notice: Feeling unusually full after meals Mild bloating Reduced appetite Occasional nausea Fatigue that feels out of proportion Because trust me when I say these symptoms are not dramatic, they are often brushed aside