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ChaC2 is constitutively expressed and exhibits catalytic efficiency for GSH 10-20 times weaker than that of ChaC1 (47)

Biol Pharm Bull 31, 986989 (2008)

Factors such as side effects, high out-of-pocket costs, injection fatigue and stigma around obesity treatment drive troves of patients some studies estimate roughly half or more to stop GLP-1s within a year and risk regaining the weight they lost

The mean percentage weight reductions were -7.3 %, -8.3 % and -10.8 % for the 2 mg, 8 mg and 16 mg doses respectively, compared to -2.0 % with placebo (treatment policy estimand, i.e