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Four reasons GLP-1s affect sleep Circadian rhythm disruption GLP-1 receptors in the hypothalamus modulate GABA, orexin, and melatonin, shifting sleep-wake cycles Blood sugar fluctuations Your body adjusts to new overnight glucose patterns, disrupting sleep cycles during adaptation Physical side effects Night sweats, digestive discomfort, and nausea peak during the first 46 weeks and dose escalation periods Psychological factors Adjusting to a new relationship with food and body image can trigger anxiety or racing thoughts at night Free Resource Get Dr

Some symptoms of lactic acidosis include: trouble breathing dizziness or lightheadedness weakness loss of appetite flushing (temporary warmth, redness, or deepening of skin color) abdominal pain muscle pain vomiting nausea What might help If you notice symptoms of lactic acidosis, contact a healthcare professional right away

Retatrutide takes a different approach